Potential for gene-gene confounding bias in case-parental control studies
Journal
Annals of Epidemiology
Journal Volume
13
Journal Issue
4
Pages
261-266
Date Issued
2003
Author(s)
Ho Y.-Y.
Abstract
PURPOSE: To show the potential for gene-gene confounding bias in case-parental control studies. METHODS: The authors quantify the magnitude of gene-gene confounding bias using simple mathematical equations. They also demonstrate the potential problems of such a bias with hypothetical (but realistic) examples. RESULTS: The degree of bias resulting from gene-gene confounding was found to be quite substantial under certain conditions (two genes are very closely linked and/or the study was performed in a recently admixed population). CONCLUSION: In this post-genomic era more and more encounters of the gene-gene confounding will be expected, if the one-gene-at-a-time approach continues to be adopted. ? 2003 Elsevier Science Inc. All rights reserved.
SDGs
Other Subjects
article; gene locus; genomics; hypothesis; mathematical model; priority journal; Bias (Epidemiology); Confounding Factors (Epidemiology); Epidemiologic Methods; Epidemiology, Molecular; Genetic Predisposition to Disease; Humans
Type
journal article