Coding of DNA Microbeads Array for Error Detection and Correction
Date Issued
2005
Date
2005
Author(s)
Wang, Jen-Yi
DOI
zh-TW
Abstract
This study developed a modulo p error correcting scheme to improve the reliability of microbeads microarrays. Microbeads microarrays have higher density than typical planar arrays due to the tiny microbeads that are randomly distributed into the wells of etched fibers. Microbeads microarrays utilize the sequential hybridizations of specific oligonucleotides with distinguishable fluorescent dyes, complementary to bead identifier sequences, for registering the location of each probe which is initially unknown. The modulo p error correcting scheme was designed to correct the error from the mistaken hybridizations that lead to misclassifying microbeads.
The concept of modulo p error correcting scheme was originated from the channel coding in communication field. This study employs multiple fluorescent levels which represent various symbols different from the binary system in digital communication and further extends its modulo 2 coding to the modulo p. The length of codewords could be shortened because each character contains options with various fluorescent dyes. The modulo p error correcting scheme not only improves the reliability of identification but also reduces the cost of microbeads microarray.
Subjects
微陣列
微珠陣列晶片
通道編碼
錯誤控制碼
Microarray
Microbeads microarray
Channel coding
Error control coding
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-94-R92631022-1.pdf
Size
23.31 KB
Format
Adobe PDF
Checksum
(MD5):244c20f077accc41f5edda0ca19a681b