Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana
Journal
Journal of Food and Drug Analysis
Journal Volume
31
Journal Issue
4
Pages
739
Date Issued
2023-01-01
Author(s)
Abstract
Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5-and 2.3-fold than the negative control). This procedure yielded bioactive indolizidine alkaloids with novel structures.
Subjects
Boehmeria formosana | GLP-1-enhancing ability | Phenanthroindolizidine alkaloids | Secondary metabolites | α-glucosidase inhibitor
SDGs
Type
journal article