鼻咽癌與DNA修補基因之流行病學研究(IV)
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
鄭玉娟
DOI
932320B002085
Abstract
Genetic polymorphisms of DNA repair
genes have been reported to determine
susceptibility to several cancers. This study
focused on effects of genetic polymorphisms of
DNA repair genes NQO1 and XPD156
interacted with environmental factor on the
development of nasopharyngeal carcinoma(NPC). The incidence of nasopharyngeal carcinoma
in Chinese is the highest in the world. It is
20-30 times compared to Caucasian, and also
much more than Japanese and Korean.
Compared to other cancers, the peak of
nasopharyngeal carcinoma more frequently
occurs in younger age and dominant in male.
The impact of the disease especially can not be
ignored. The specific aim of this study is to
explore the risk factors of nasopharyngeal
carcinoma (NPC). A case-control study for
NPC which was collaborated with College of
Medicine, College of Public Health National
Taiwan University and the National Institute of
Health in America was conducted in Taiwan
from July 1991 to December 1994 to
investigate the interaction of environmental
carcinogen and genotype polymorphism to the
risk of NPC. We enrolled 355 histologically
confirmed incident NPC cases who were
younger than 75 years old, and had resided in
Taipei city/county for at least 6 months, from
National Taiwan University Hospital and
Mackay Memorial Hospital. Totally 283
healthy community controls were selected by
individual matching for sex, age and residence.
The study will use the real-time polymerase
chain reaction (RTPCR) to analyze the geno
types of DNA repair genes NQO1 and XPD156. Information of Risk factors were obtained
through personal interview with structured
questionnaire, in which included demographic
factors, the history of smoking, drinking,
dietary habit, family history of cancer etc. The
information were combined with genotyping
results to evaluate the effect of NPC development. Unconditional logistic regression
was performed to clarify the relationship
between various risk factors, genetic
susceptibility and NPC occurrence, and also to
elucidate their interaction. After adjusting age,
sex, ethnicity, educational level, and duration
of smoking, NPC is not associated with genetic
polymorphisms of NQO1 and XPD156. We
further stratified by anti-EBV antibodies,
occupational exposure to wood dust and
formaldehyde, and dietary nitrosamine intake.
When stratified 0-10 years exposure to either
formaldehyde or wood dust, NPC risk is
significantly correlated with NQO1
polymorphism, while remained no significant
association between NPC risk and XPD156.
Subjects
nasopharyngeal carcinoma
case-control study
risk
factor
factor
DNA repair genes
genetic polymorphism
susceptibility
SDGs
Publisher
臺北市：國立臺灣大學公共衛生學院流行病學研究所
Type
report
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