Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides
Resource
J Sci Food Agric.,91(12),2284-2291.
Journal
Journal of the Science of Food and Agriculture
Journal Volume
91
Journal Issue
12
Pages
2284-2291
Date Issued
2011
Author(s)
Liu, Chin-Feng
Tseng, Kuo-Chuan
Chiang, Shen-Shih
Lee, Bao-Hong
Hsua, Wei-Hsuan
Abstract
Immunomodulation by probiotic microorganisms has become a topic of increasing interest in food microbiology. Polysaccharides are broadly used in the food industry as gelling, thickening, stabilizing, or emulsifying agents. Some probiotics such as lactic acid bacteria also produce exopolysaccharides that stimulate macrophage production of cytokines. The aim of this study was to characterize the effects of exopolysaccharides of Lactobacillus paracasei subsp. paracasei NTU 101 (101EP) and Lactobacillus plantarum NTU 102 (102EP) exopolysaccharides on antioxidant activity and immunomodulation in vitro. The sugar composition (including arabinose, galactose, glucose, fructose, mannose, and maltose) of 101EP and 102EP was quantified by high-performance anion-exchange chromatography. Cytokine production (including IL-6, TNF-α, and IL-1β) was induced by 101EP and 102EP in Raw 264.7 in a dose-dependent manner (5-500 µg mL(-1) ). 101EP and 102EP also demonstrated potential antioxidant properties (1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, chelation of ferrous ions, inhibition of linoleic acid peroxidation, and reducing power) in vitro. 101EP and 102EP stimulate cell proliferation and may be useful as a mild immune modulator of macrophages.
SDGs
Type
journal article