Investigation of the Spatial and Temporal Distribution of Nanoparticles in Isolated and Subcutaneous Tumors
Date Issued
2014
Date
2014
Author(s)
Chang, Wan-I
Abstract
The distribution and accumulation of nanoparticle dosage in a tumor are important in evaluating the effectiveness of cancer treatment. The transportation of nanoparticles in a tumor is affected by many factors such as the sizes of the tumor and necrotic region, vascular density and its distribution in the tumor, and the characteristics of nanoparticles. We developed a mathematical tumor model based on the governing equations for the fluid flow to investigate the drug transportation in a tumor and computed the resulting accumulative concentration. Moreover, the cell survival rate, which was calculated with the help of the accumulative concentration, was evaluated to quantify the therapeutic effect. The survival rates after multiple treatments are helpful to evaluate the efficiency of the chemotherapy plan.
The model was applied to both an isolated tumor and a subcutaneous tumor with heterogeneous vascular distribution, and various dextrans were chosen as the nanodrug carrier to study the impact of the sizes of tumor and necrotic region and vascular surface area per unit tumor volume ( ) on the average accumulative concentration. Furthermore, doxorubicin was chosen as the traditional chemotherapeutic agent and the treatment effect was compared with that of dextrans. The results showed that: 1) large nanoparticles produced a large accumulative concentration in the well-vascular region, but low dose in the necrotic region; 2) small nanoparticles can penetrate into the necrotic region; however, its accumulative concentration was low and was more toxic to normal tissues; 3) the influence of the tumor size on the average accumulative concentration was much more pronounced for small nanoparticles, while the effect of was relatively more significant when employing large nanoparticles; 4) the treatment effect of nanoparticles on tumor is better than traditional chemotherapeutic agent and the damage on normal tissue is much smaller as well. The results indicated that the effectiveness of the anti-tumor drug delivery was determined by the interplay of the vascular density and nanoparticle size, and using nanoparticles as anti-tumor drug is better because its high treatment efficiency on tumors and less damage to normal tissues.
Subjects
奈米藥物載體
藥物傳輸
腫瘤模擬
細胞存活率
SDGs
Type
thesis
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