Verification and evaluation of aldosteronism demographics in the Taiwan Primary Aldosteronism Investigation Group (TAIPAI Group)
Journal
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Journal Volume
12
Journal Issue
3
Pages
348-357
Date Issued
2011
Author(s)
Kuo C.-C.
Tsai C.-W.
Lee T.-Y.
Lin Y.-H.
Lin C.-Y.
Chang H.-W.
Wang W.-J.
Kao T.-W.
Abstract
Objective: Current data on primary aldosteronism (PA) from Asian populations are scarce. This cohort study clarifies the attributes of patients with PA in a typical Chinese population. Design: An observational cohort study. Methods: The records of patients referred to the Hypertension Clinic from a multi-centre registration in Taiwan from January 1995 to December 2007 were reviewed. All patients with PA were classified into two subtypes: aldosterone-producing adenomas (APA) and idiopathic hyperaldosteronism (IHA); their characteristics were compared. Results: Our cohort consisted of 346 patients with PA, 255 with APA and 91 with IHA. The initial hypokalaemia (59% in APA vs. 27.5% in IHA, p < 0.0001) and transtubular potassium gradient (TTKG) (6.30 ± 2.41 in APA vs. 4.91 ± 2.03 in IHA, p = 0.01) were higher in the APA group. Baseline plasma aldosterone concentration (PAC) was also significantly different between the two subgroups (49.96 ± 38.15 ng/dl in APA vs. 34.24 ± 21.47 in IHA, p < 0.0001). Conclusions: In typical Chinese PA patients, the APA subgroup had a higher proportion of hypokalaemia with elevated TTKG and higher PAC as compared with the IHA subgroup. This largest Asian database also demonstrated major differences between the Caucasian and Chinese populations including female predilection, frequent hypokalaemia, and common paralytic myopathy. ? 2011 The Author(s).
SDGs
Other Subjects
aldosterone; alpha adrenergic receptor blocking agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; captopril; dipeptidyl carboxypeptidase inhibitor; diuretic agent; potassium; spironolactone; adrenal scintiscanning; adrenalectomy; adult; age; aldosterone blood level; aldosterone producing adenoma; aldosterone urine level; article; body height; body mass; body weight; brain hemorrhage; Caucasian; Chinese; chronic kidney failure; controlled study; diabetes mellitus; diastolic blood pressure; disease duration; evaluation; female; follow up; gender; heart rate; histopathology; human; human tissue; hyperaldosteronism; hypertension; hypokalemia; idiopathic hyperaldosteronism; incidentaloma; major clinical study; male; maternal hypertension; medical parameters; medical record review; nephrolithiasis; observational study; paralysis; patient coding; polymerase chain reaction; potassium blood level; race; retrospective study; rhabdomyolysis; seizure; sodium excretion; transtubular potassium gradient; Adenoma; Aldosterone; Cohort Studies; Demography; Female; Humans; Hyperaldosteronism; Hypertension; Male; Mass Screening; Prevalence; Reproducibility of Results; Taiwan
Type
journal article