Fusarium solani species complex infection in elasmobranchs: A case report for rough-tail stingray with valid antifungal therapy
Journal
Medical Mycology Case Reports
Journal Volume
32
Pages
34-38
Date Issued
2021
Author(s)
Abstract
Fusarium species are common plant and animal pathogens. For humans, there are two dominant species complexes, F. solani species complex (FSSC) and F. oxysporum species complex (FOSC), which both infect immunocompromised individuals. However, there are few reports related to elasmobranchs infected by Fusarium species. In this study, we report a case of a rough-tail stingray from an ocean park infected by FSSC diagnosed using histopathology and microscopic observation, with morphological characteristics and molecular techniques used to identify the pathogen. Histopathology showed fungal hyphae invading stingray tissues, while micro/macroconidia were found under the microscope. We identified this pathogen as FSSC 12 through phylogenetic analysis using internal transcribed spacer (ITS) and elongation factor 1-alpha (EF1-α) sequences. Furthermore, we report that application of voriconazole (orally) and terbinafine (topically) constituted an effective therapy, curing the stingray. ? 2021
Subjects
dimethyl sulfoxide; elongation factor 1alpha; enrofloxacin; internal transcribed spacer; iodine; itraconazole; merbromin; methylene blue; salicylic acid; terbinafine; tricaine; voriconazole; animal cell; animal tissue; antifungal susceptibility; antifungal therapy; Article; DNA sequence; drug substitution; drug withdrawal; elasmobranch; fungus hyphae; fungus identification; fusariosis; Fusarium solani; histopathology; microscopy; morphological trait; nonhuman; phylogeny; priority journal; rough tail stingray; secondary infection; species complex; water quality
Type
journal article