人類第四型多巴胺受器在腎上腺皮質醛酮瘤的表現及其多型性的臨床意義
Date Issued
1999
Date
1999
Author(s)
吳寬墩
DOI
882314B002234
Abstract
The aldosterone secretion is evidently regulated by a dopaminergic inhibitory
mechanism. Pharmacological characterization and autoradiographic studies revealed a D2-like
receptor in the adrenal cortex, especially in the zona glomerulosa (ZG). However, the subtype
of the dopamine receptors (DR) involving this regulation is not elucidated, although a D2-like
receptor was suspected. To investigate which subtype of DR expresses in the adrenal cortex,
we examined the messages of D2-like receptors, D2, D3 and D4, by RT-PCR and in situ
hybridization of adrenal glands and adrenal neoplasm. Both D2 and D4 receptors were
expressed in normal adrenal gland, pheochromocytoma and aldosterone-producing adenoma
(APA). However, D2 receptor was not universally expressed in all adrenal samples in contrast
with D4 receptor that was detected in all cases of APA and adrenal remnant. No D3 message
was detected by RT-PCR in all adrenal samples. In the adrenal cortex, the messages of D2
and D4 were mainly localized in the ZG and, to a lesser extent, in the zona reticularis. In APA,
the non-zona fasciculata-like cells expressed D4 and D2 receptors more abundantly than zona
fasciculata-like cells. In summary, we demonstrated the existence of both D2 and D4
receptors in the human adrenal gland and adrenal neoplasm. The expression of both DR in the
adrenal cortex is mainly localized in the ZG. This observation indicates that both DR may
play a role in the regulation of aldosterone secretion.
Subjects
多巴胺受器
皮質醛酮瘤
腎上腺
多形性
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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