大麻使用與焦慮之因果關係：雙樣本孟德爾隨機化研究
Other Title
Causality between Cannabis Use and Anxiety: A Two-Sample Mendelian Randomization Study
Journal
2024臺大學士論文獎
Date Issued
2024
Author(s)
Yong-Sheng Wong
Advisor
Abstract
Research has suggested that cannabis use is a modifiable behavioral factor associated with anxiety, which in turn may influence cannabis use. However, the causality between cannabis use and anxiety is yet to be elucidated. We conducted a bidirectional, two-sample Mendelian randomization investigation leveraging the latest publicly available genome-wide association study summary statistics to explore potential causal relationships between lifetime cannabis use (LCU), cannabis use disorder (CUD), and anxiety disorders among individuals of European ancestry. Using the inverse-variance weighted (IVW) multiplicative random-effects model, with the median- and mode-based estimates, MR-Egger, MR-PRESSO, and other supplementary analyses, positive causal effects were found in several tests: CUD on anxiety disorders (ORIVW = 1.088, 95% CI: 1.018-1.163, p-value = 0.013), CUD on social phobias (ORIVW = 1.290, 95% CI: 1.062-1.567, p-value = 0.010), and anxiety disorders on LCU (ORIVW = 1.166, 95% CI: 1.007-1.351, p-value = 0.040). Our findings align with existing epidemiological evidence, but on the whole, this study alone may not offer compelling evidence to confirm the causal associations between cannabis use and anxiety. Discrepant results with the literature may arise from confounding or reverse causation in observational studies, as well as differences between genetic instrumental variable analysis and clinical trials or community interventions. To boost the power to detect causality and improve the generalizability of research findings, future efforts should be made for the richness and diversity of omics data. This includes identifying more specific genetic markers linked to cannabis use or anxiety with biomedical implications. Most importantly, evidence synthesis and triangulation, along with critical appraisal of causal fallacies, will provide better guidance for substance use issues and mental health practices.
Subjects
Mendelian randomization
cannabis
anxiety
causal inference
genetic instrumental variables
Publisher
國立臺灣大學公共衛生學系
Description
指導教授：郭柏秀
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
公衛系_翁咏聖(已保全).pdf
Size
3.81 MB
Format
Adobe PDF
Checksum
(MD5):18730ece12d95a3f975b83895d972886