Expression of Placental Growth Factor (PLGF) andascular Endothelial Growth Factor (VEGF) in Oralormal Mucosa, Oral Dysplasia and Oral Squamousell Carcinoma: an Association with Clinicalharacteristics and Survival
Date Issued
2009
Date
2009
Author(s)
Chou, Chia-Hsuan
Abstract
Background:ascular endothelial growth factor-A (VEGF-A, abbrev. VEGF) and placenta growth factor (PLGF) belong to VEGF family. VEGF could induce tumor angiogenesis through binding to VEGFR-2, which was highly expressed in a variety of human cancers, including oral cancer. Over-expression of PLGF was known to be associated with pathological angiogenesis. The study examined PLGF expression at the protein level in oral cancer and oral epithelial dysplasia, in which no reports on the significance of PLGF expression is available to date.aterial and Method:n this study, we examined the expression of VEGF and PLGF in 100 specimens of oral squamous cell carcinoma (OSCC)、66 specimens of oral epithelial dysplasia (OED) and 36 specimens of normal oral mucosa (NOM) by immunohistochemistry. The correlation between the expression of VEGF and PLGF in OSCCs and clinicopathological parameters or survival of OSCC patients was analyzed by ANOVA, Chi-square and Kaplan-Meier survival analysis. Univariate and multivariate analyses (Cox proportional hazard regression model) were used to find the correlation between expression of VEGF and PLGF, clinicopathological parameters and survival, and try to seek independent predictors for survival time.esults:he labeling indices of VEGF from NOM (13%±6), mild dysplasia (22%±8), moderate dysplasia (24%±13), severe dysplasia (32%±14) to OSCC (50%±18: the most abundant) were noted (p<0.001). PLGF expression increased as samples ranged from NOM (12%±4), mild dysplasia (20%±9), moderate dysplasia (26%±11), severe dysplasia (30%±13) to OSCC (51%±19: the most abundant) was noted (p<0.001). The VEGF and PLGF expression correlated with gender, lymph node status and clinical stage (p<0.05).Multivariate analysis demonstrated that lymph node metastasis, VEGF LI>40%, PLGF LI>40% and VEGF-PLGF LI>40% were independent predictors for the survival time.It was noteworthy that when VEGF-PLGF was expression above 40% concomitantly, which raised the hazard ratio to 5.596.onclusion:n this study, PLGF and VEGF expression were significantly higher in OSCC than that in NOM and OED. In addition, VEGF and PLGF were correlated with some clinical parameters and survival. Synergism between VEGF and PLGF contributed to higher hazard ratio, and shorter survival time. VEGF and PLGF may be prognostic factors for OSCC patients.
Subjects
vascular endothelial growth factor
placenta growth factor
oral squamous cell carcinoma
oral epithelial dysplasia
SDGs
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