Demand feeding for healthy premature newborns: A randomized crossover study

Background and Purpose: In hospitals, preterm infants are routinely fed specified amounts of formula on a fixed schedule. This results in the baby's intake volume being regular and easily confirmed, but does not consider the individual baby's needs. The purpose of this study was to compare the effects of demand feeding and fixed schedule feeding for healthy premature newborn babies. Methods: A 2-feeding-type, 2-period crossover study design was employed, in which each period consited of 2 days, the first of which was a washout period, comprising a self-comparison protocol designed to identify any differences in the feeding characteristics of premature infants on demand or scheduled bottle-feeding. Eleven preterm infants were included. The sample size was monitored during the observation period by power calculation. The mean weight at study entry was 1897.27 ± 175.94 g and the mean postconceptional age was 35.34 ± 1.54 weeks. Results: Compared with scheduled feeding, demand feeding was associated with a longer daily mean interval (4.17 vs 3.02 hours; p=0.00), greater volume per feed for demand feeding (67.28 vs 51.11; p=0.00), greater feeding speed (5.73 vs 4.51 mL/min; p=0.00), but a similar daily total duration of feeding. There was no significant difference in the daily total feeding volume. Conclusions: Demand feeding provides superior volume per feed, and feeding speed and shortens the duration of feeding compared to feeding on a routine schedule. It is suitable and feasible for healthy premature newborns.