急性呼吸窘迫症候群BAL及肺組織之黏液醣蛋白及其基因的表現 (I)
Other Title
Mucin and mucin gene expression in BAL and lung tissue of patients with
ARDS(I)
ARDS(I)
Date Issued
1999
Date
1999
Author(s)
楊泮池
DOI
882314B002206
Abstract
Mucins are high molecular weight
glycoproteins (MW>200kD) present in
the human airway with the function of
protection and lubrication. Acute respiratory distress syndrome (ARDS)
represents a severe, diffuse lung injury
caused by a wide variety of insults. The
overwhelming inflammatory cells and
mediators result in disruption of the
alveolocapillary membrane, and leakage
of a protein-rich fluid into the alveolar
airspaces. Our previous study showed
serum levels of mucin-associated antigen
elevated in patients with ARDS. Serial
measurements of serum mucin levels were
inversely correlated with static respiratory
system compliance and log (PaO2/FiO2),
and positively correlated with lung injury
score. The serum mucins of patients with
ARDS were polydispersed and smaller
than the antigens in normal sera. We
hypothesize that elevated serum mucin is
due to increased production, increased
permeability or increased degradation to
smaller molecules before or after they
gain access into blood stream. In this
project, we used immunohistochemical
stains to evaluate mucin expression in
lung tissue of patients with ARDS in
comparison with the values of control
groups. We want to compare the pattern
of mucin genes expression in ARDS and
normal lung tissue; as a basis to study the
mucin genes expression in inflammation.
Subjects
Mucins
Acute Respiratory
Distress Syndrome
Distress Syndrome
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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