Inflammatory effects of menthol vs. non-menthol cigarette smoke extract on human lung epithelial cells: A double-hit on TRPM8 by reactive oxygen species and menthol
Journal
Frontiers in Physiology
Journal Volume
8
Journal Issue
APR
Pages
263
Date Issued
2017
Author(s)
Abstract
and IL-8 compared with Non-M-CSE alone. Moreover, we confirmed the essential role of TRPM8 in these responses to Non-M-CSE or M-CSE and the difference in these responses between the both CSE types using HBECs with TRPM8 knockdown and TRPM8 knockout, and using HEK293 cells transfected with hTRPM8. Thus, compared with exposure to Non-M-CSE, exposure to M-CSE induced greater TRPM8-mediated inflammatory responses in HBECs. These augmented effects may be due to a double-hit on lung epithelial TRPM8 by ROS generated from CSE and the menthol in M-CSE.
SDGs
Publisher
Frontiers Research Foundation
Type
journal article