Risk of new-onset autoimmune diseases in primary aldosteronism: a nation-wide population-based study
Journal
Journal of hypertension
Journal Volume
38
Journal Issue
4
Pages
745-754
Date Issued
2020
Author(s)
Er L.K.
Chen L.
Tsai Y.-C.
Huang W.-C.
TAIPAI Study Group
Abstract
OBJECTIVE: The association between hyperaldosteronism and autoimmune disorders has been postulated. However, long-term incidence of a variety of new-onset autoimmune diseases (NOAD) among patients with primary aldosteronism has not been well investigated. METHODS: From Taiwan's National Health Insurance Research Database with a 23-million population insurance registry, the identification of primary aldosteronism, essential hypertension and NOAD as well as all-cause mortality were ascertained by a validated algorithm. RESULTS: From 1997 to 2009, 2319 primary aldosteronism patients without previously autoimmune disease were identified and propensity score-matched with 9276 patients with essential hypertension. Among those primary aldosteronism patients, 806 patients with aldosterone-producing adenomas (APA) were identified and matched with 3224 essential hypertension controls. NOAD incidence is augmented in primary aldosteronism patients compared with its matched essential hypertension (hazard ratio 3.82, P?
SDGs
Other Subjects
adrenal cortex adenoma; adrenal cortex tumor; adrenalectomy; adult; autoimmune disease; comorbidity; essential hypertension; factual database; female; human; hyperaldosteronism; incidence; male; middle aged; Taiwan; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adult; Autoimmune Diseases; Comorbidity; Databases, Factual; Essential Hypertension; Female; Humans; Hyperaldosteronism; Incidence; Male; Middle Aged; Taiwan
Type
journal article