結合理論計算與實驗方法定量分析溶劑對生物醫學用共聚合物的選擇性及其微結構的影響(1/2)
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
DOI
922216E002033
Abstract
Block copolymer solutions can self-assemble into various microstructures due to the effects of
solvent selectivity. Though most of the related experimental and theoretical results are
qualitatively consistent, there exists little quantitative comparison between both fields. This is due
to the fact that it is difficult to determine the solvent selectivity in real systems. Therefore, we aim
to quantitatively determine the interaction parameters between each block and the solvent by
comparing both experimental and numerical results. We consider a poly(ethylene-glycol)
-polylactide (PEG-PLLA) diblock copolymer. In particular, PLLA component can crystallize
below the melting temperature. As PLLA is biodegradable and PEG is non-toxic to human bodies,
these materials play a very important role on the biomedical research. We first focus on the
crystallization as well as the structure analysis of PEP-PLLA copolymer melts. We then analyze
the dilute copolymers in the presence of selective solvents. With the aid of rheology
measurements, dynamic light scattering, and small-angle neutron scattering, the structural
parameters, such as micelle shape and size, are analyzed and compared with the numerical results.
As such, we can determine the interaction parameters between PEG-solvent and PLLA-solvent.
Once the solvent selectivity is obtained, we determine the corresponding phase diagrams of
PEG-PLLA block copolymer solutions by self-consistent mean-field theory.
Subjects
block copolymer solutions
self-assembly behavior
solvent selectivity
scaling of
microdomain spacing
microdomain spacing
self-consistent mean-field theory
Publisher
臺北市：國立臺灣大學高分子科學與工程學研究所
Type
report
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