猴病毒四十型T/t-common基因用於治療HER-2/neu大量表現的癌症的評估（2/3）
Date Issued
2004
Date
2004
Author(s)
王萬波
DOI
923112B002008
Abstract
In the previous report, we have demonstrated that T/t-common could
specifically induce apoptosis in HER-2/neu-overexpressing cancer cells but not in
HER-2/neu low-expressing cancer cells and normal cells. To investigate whether this
is the general property of T/t-common, for the past year, we included more
HER-2/neu-overexpressing and HER-2/neu low-expressing cancer cells and normal
cells in our study. The results confirm our previous conclusion and indicate that
T/t-common may be developed as a selective therapeutic agent against
HER-2/neu-overexpressing cancers. We also demonstrated that T/t-common induced
apoptosis of HER-2/neu-overexpressing cancer cells by activating the caspase activity
and that the ability of T/t-common to induce apoptosis could be inhibited by Bcl-2. As
regard to the mechanism underlying T/t-common induction of apoptosis, we found
that T/t-common induced apoptosis in HER-2/neu-overexpressing cancer cells
primarily by repressing HER-2/neu expression. Finally we demonstrated that
T/t-common could sensitize HER-2/neu-overexpressing cancer cells to anti-cancer
drug cisplatin. We also showed that T/t-common could inhibit angiogenesis induced
HER-2/neu-overexpressing cancer cells. Taken together, these data suggest that
T/t-common may be developed as an efficient anti-cancer gene therapy agent.
Subjects
HER-2/neu
SV40
T/t-common
Apoptosis
Angiogenesis
SDGs
Publisher
臺北市：國立臺灣大學醫學院免疫學研究所
Type
journal article
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