Heterogeneous reduction of myocardial oxidative metabolism in patients with ischemic and dilated cardiomyopathy using C-11 acetate PET
Journal
Circulation Journal
Journal Volume
72
Journal Issue
5
Pages
786-792
Date Issued
2008
Author(s)
Abstract
Background: The 11C-acetate positron emission tomography can estimate myocardial oxidative metabolism, but previous studies have only evaluated small populations and the difference between ischemic (ICM) and idiopathic dilated cardiomyopathy (DCM) has not been fully investigated. The present aims were to evaluate global and regional myocardial oxidative metabolism in a well-characterized, large population with left ventricular (LV) dysfunction in order to clarify the metabolic differences between ICM and DCM. Methods and Results: Seventy-eight patients with ejection fraction (EF) ?50% (33 ICM; 45 DCM) were compared with 14 healthy controls. Myocardial oxidative metabolism was estimated with a clearance rate constant (Kmono) and the coefficient of variation (CV) of regional Kmono. Patients with LV dysfunction had reduced Kmono and higher CV (p<0.05). In the comparison of oxidative alterations with clinical variables there was a weak correlation between Kmono and LVEF (r=0.27). Although Kmono was reduced in both ICM and DCM, CV was more pronouncedly increased in ICM (p=0.001). In multivariate analysis, the presence of left bundle branch block (LBBB) was an independent predictor of heterogeneous oxidative metabolism in DCM (R2=0.30, p<0.0001). Conclusions: Global reduction of myocardial oxidative metabolism occurred in both ICM and DCM. Heterogeneous oxidative metabolism was observed in these patients, especially those with ICM. Furthermore, LBBB was the independent predictor of heterogeneous oxidative metabolism in patients with DCM.
SDGs
Other Subjects
acetic acid c 11; adult; aerobic metabolism; article; cardiomyopathy; clearance; comparative study; congestive cardiomyopathy; controlled study; female; heart ejection fraction; heart left bundle branch block; heart left ventricle failure; heart muscle; human; human tissue; ischemic cardiomyopathy; major clinical study; male; multivariate analysis; population; positron emission tomography; predictor variable; statistical significance; Acetates; Aged; Bundle-Branch Block; Carbon Radioisotopes; Cardiomyopathy, Dilated; Energy Metabolism; Female; Heart; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Myocardium; Oxygen; Positron-Emission Tomography; Predictive Value of Tests
Type
journal article