Enhanced Poly(SBMA/HEMA) Hydrogels: Superior Toughness, Biocompatibility, and Antibacterial Efficacy
Journal
ACS Applied Polymer Materials
Journal Volume
6
Journal Issue
19
Start Page
12329
End Page
12340
ISSN
2637-6105
2637-6105
Date Issued
2024-10-01
Author(s)
Abstract
This study investigates the mechanical and biological properties of hydrophobically associated poly(sulfobetaine methacrylate-co-2-hydroxyethyl methacrylate) (poly(SBMA/HEMA)) hydrogels synthesized via micellar copolymerization. These hydrogels exhibit remarkable toughness and self-healing capabilities due to their reversible cross-linked networks. Experimental results indicate that increasing the HEMA content enhances the tensile modulus but reduces elongation and toughness. By optimizing the ratio of SBMA to HEMA, the hydrogels can maintain tensile strength, self-healing properties, adhesiveness, and biocompatibility. Additionally, these hydrogels can encapsulate hydrophobic curcumin, promoting controlled drug release and demonstrating effective antibacterial properties, highlighting their potential for biomedical applications. This research pioneers the preparation of hydrogels using hydrophobic association mechanisms, differing from chemically cross-linked poly(SBMA/HEMA) hydrogels, not only improving mechanical properties but also providing an effective approach for encapsulating hydrophobic drugs within hydrogels.
Publisher
American Chemical Society (ACS)
Type
journal article