Quantitative 3D analysis of tissue damage in a rat model of microembolization
Journal
Journal of Biomechanics
Journal Volume
128
Date Issued
2021
Author(s)
Payne S.
van der Wijk A.-E.
Bakker E.N.T.P.
vanBavel E.
Majoie C.
Marquering H.
van Bavel E.
Hoekstra A.
Dippel D.
Lingsma H.
van der Lugt A.
Samuels N.
Boodt N.
Roos Y.
de Meyer S.
Staessens S.
Vandelanotte S.
Konduri P.
Terreros N.A.
Chopard B.
Raynaud F.
Petkantchin R.
Panteleev M.
Shibeko A.
Boudjeltia K.Z.
Blanc-Guillemaud V.
Migliavacca F.
Dubini G.
Luraghi G.
Matas J.F.R.
Bridio S.
Mc Garry P.
Gilvarry M.
McCarthy R.
Moerman K.
Fereidoonnezhad B.
Dwivedi A.
Duffy S.
Payne S.
Jozsa T.
Georgakopoulou S.
Padmos R.
Azizi V.
Miller C.
Abstract
There is a discrepancy between successful recanalization and good clinical outcome after endovascular treatment (EVT) in acute ischemic stroke patients. During removal of a thrombus, a shower of microemboli may release and lodge to the distal circulation. The objective of this study was to determine the extent of damage on brain tissue caused by microemboli. In a rat model of microembolization, a mixture of microsphere (MS) sizes (15, 25 and 50 ?m diameter) was injected via the left internal carotid artery. A 3D image of the left hemisphere was reconstructed and a point-pattern spatial analysis was applied based on G- and K-functions to unravel the spatial correlation between MS and the induced hypoxia or infarction. We show a spatial correlation between MS and hypoxia or infarction spreading up to a distance of 1000–1500 ?m. These results imply that microemboli, which individually may not always be harmful, can interact and result in local areas of hypoxia or even infarction when lodged in large numbers. ? 2021 The Authors
Subjects
Endovascular therapy
Hypoxia
Incomplete microvascular reperfusion
Microembolization
Spatial analysis
Stroke
Blood vessels
Hemodynamics
Patient treatment
Spatial variables measurement
Three dimensional computer graphics
Tissue
Endovascular
Microemboli
Microvascular
Reperfusion
Rats
animal
brain
brain ischemia
cerebrovascular accident
endovascular surgery
human
internal carotid artery
rat
treatment outcome
Animals
Brain
Brain Ischemia
Carotid Artery, Internal
Endovascular Procedures
Humans
Treatment Outcome
Type
journal article