Correlation between chemokine level and severity of psoriasis
Date Issued
2006
Date
2006
Author(s)
Chen, Chih-Kang
DOI
zh-TW
Abstract
Background: Infiltrating neutrophils play a key role in pathogenesis of psoriasis. Chemokines are involved in leukocyte homing and contribute to inflammatory process in psoriatic skin lesions. Objective: To investigate the possible chemokine index for the assessment of the disease severity. Methods: Serum concentrations of chemokines IP-10, MCP-1, MIG, RANTES, and IL-8 were assayed in 16 psoriasis patients with serial sampling and 50 healthy controls by immunofluorescence flow cytometry with beads array. Results: Serum IP-10, MIG concentrations in psoriasis patients were higher than in controls (p<0.0001), and correlated significantly with PASI score. While serum RANTES, IL-8 in psoriasis patients were lower than in controls (p<0.05). No significant differences in urine and saliva chemokines concentrations among all groups. Conclusions: Serum IP-10 levels fits well with PASI score in psoriasis patients, even under different treatment regimen. It may be used as parallel parameter for PASI score in researching of psoriasis.
Subjects
乾癬
化學激素
T細胞
psoriasis
chemokine
Th1
Type
text
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