Preparation and characterization of pH sensitive poly(N-vinyl-2- pyrrolidone/itaconic acid) copolymer hydrogels
Journal
Materials Chemistry and Physics
Journal Volume
91
Journal Issue
2-3
Pages
484-489
Date Issued
2005
Author(s)
Abstract
Poly(N-vinyl-2-pyrrolidone) (PVP) is widely used in medicine due to its high biocompatibility. In this study, itaconic acid (IA) was co-polymerized with N-vinyl-2-pyrrolidone (NVP) monomer to prepare the pH sensitive hydrogels. These copolymer hydrogels were prepared using ultra-violet (UV) induced methods at ambient temperature. Monomer and cross-linking agent (N,N′-methylene- bisacrylamide (MBAAm)) concentration effects on preparation of this copolymer hydrogel were investigated using swelling, FT-IR, and SEM. The prepared copolymer hydrogel is highly pH sensitive. The percentage swell of the copolymer hydrogels was found to increase from 150 to 3011% as the pH value of the swelling solution varied from 4 to 10. These pH sensitive copolymer hydrogels present a promising approach for drug delivery applications. © 2004 Elsevier B.V. All rights reserved.
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Type
journal article
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