Rapid detection of chinese Gγ+(Aγδβ)°-thalassemia by polymerase chain reaction
Journal
Acta Haematologica
Journal Volume
89
Journal Issue
2
Pages
80-81
Date Issued
1993
Author(s)
Abstract
The Chinese G gamma+(A gamma delta beta)zero-thalassemia is caused by a deletion of more than 80 kilobases. It has a beta(+)-thalassemia phenotype and should be differentiated from other mutations causing beta-thalassemia. Using polymerase chain reaction with three oligonucleotide primers bridging the breakpoints, the deletion can be detected easily. The method is useful in the genetic counseling and prenatal diagnosis of the at-risk families.
Type
journal article