A rare cause of childhood-onset nephrotic syndrome: Lipoprotein glomerulopathy
Journal
Clinical Nephrology
Journal Volume
78
Journal Issue
3
Pages
237-240
Date Issued
2012
Author(s)
Abstract
We report on a 12-year-old female patient with lipoprotein glomerulopathy (LPG) who was proven to be heterozygous for ApoE2 Kyoto (Arg25Cys). Her family members have the same variant but do not have obvious signs of renal function impairment. Six months of treatment with a statin caused significant clinical improvement in the lipid profile, proteinuria, and renal function. Our case suggests that administration of a statin is a potential therapeutic strategy for improving nephrotic syndrome in patients with LPG. ? 2012 Dustri-Verlag Dr. K. Feistle.
SDGs
Other Subjects
enalapril; hydroxymethylglutaryl coenzyme A reductase inhibitor; lipoprotein; methylprednisolone; pravastatin; anemia; article; case report; child; electron microscopy; female; glomerulopathy; human; human tissue; hyperlipidemia; hypertension; kidney biopsy; kidney function; lipid blood level; lipoprotein glomerulopathy; microscopy; nephrotic syndrome; non insulin dependent diabetes mellitus; pediatrics; proteinuria; rare disease; school child; urinalysis; Age of Onset; Anti-Inflammatory Agents; Antihypertensive Agents; Apolipoprotein E2; Child; Enalapril; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Methylprednisolone; Mutation; Nephrotic Syndrome; Pravastatin
Type
journal article