In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator
Journal
Annals of Biomedical Engineering
Journal Volume
49
Journal Issue
9
Start Page
2094
End Page
2102
ISSN
00906964
Date Issued
2021-09
Author(s)
Abiri, Parinaz
Duarte-Vogel, Sandra
Abiri, Arash
Gudapati, Varun
Yousefi, Alireza
Roustaei, Mehrdad
Chang, Chih-Chiang
Cui, Qingyu
Hsu, Jeffrey J.
Bersohn, Malcolm
Markovic, Dejan
Chen, Jun
Tai, Yu-Chong
Hsiai, Tzung K.
Abstract
Millions of patients worldwide are implanted with permanent pacemakers for the treatment of cardiac arrhythmias and conduction disorders. The increased use of these devices has established a growing clinical need to mitigate associated complications. Pacemaker leads, in particular, present the primary risks in most implants. While wireless power transfer holds great promise in eliminating implantable device leads, anatomical constraints limit efficient wireless transmission over the necessary operational range. We thereby developed a transmitter-centered control system for wireless power transfer with sufficient power for continuous cardiac pacing. Device safety was validated using a computational model of the system within an MRI-based anatomical model. The pacer was then fabricated to meet the acute constraints of the anterior cardiac vein (ACV) to enable intravascular deployment while maintaining power efficiency. Our computational model revealed the wireless system to operate at > 50 times below the tissue energy absorption safety criteria. We further demonstrated the capacity for ex vivo pacing of pig hearts at 60 beats per minute (BPM) and in vivo pacing at 120 BPM following pacer deployment in the ACV. This work thus established the capacity for wireless intravascular pacing with the potential to eliminate complications associated with current lead-based deep tissue implants.
Subjects
Cardiovascular devices
Implantable pacemaker
Leadless pacemaker
Wireless biomedical devices
Wireless pacemaker
Wireless power transfer
SDGs
Publisher
Springer
Type
journal article