Synthesis of Glyco-Conjugates 1. Synthesis of 2,5-Neuraminic acid dimer 2. Synthesis of Glyco-Conjugates via Olefin Metathesis
Date Issued
2004
Date
2004
Author(s)
Fan, Gang-Ting
DOI
zh-TW
Abstract
In this thesis, new methods for the synthesis of several different types of glyco-conjugates were developed. The target including natural glyco-conjugated ligand, drug mimetic and derivatives.
2,5-neuraminic acid was chosen as the first target. This glycol-conjugate was a very important signal transductor during fertilization of the sea urchin. Here, an amide bond formation reaction was used to construct the 2,5-neuraminic acid dimer. By this method, glycosidic bond was formed through an exclusive
Subjects
唾液酸
歧化反應
醣類
neuraminic acid
metathesis
c-linked
KRN7000
saccharide
ceramide
phytosphingosine
Type
thesis
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