Retinal ganglion cell-inner plexiform layer thickness is nonlinearly associated with cognitive impairment in the community-dwelling elderly
Journal
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Journal Volume
11
Pages
19-27
Date Issued
2019
Author(s)
Abstract
INTRODUCTION: Thinning of optical coherence tomography-measured retinal nerve fiber layer thickness and ganglion cell-inner plexiform layer (GC-IPL) thickness has been found in patients with Alzheimer's disease. However, the association of these retinal markers and cognition in nondemented elders may not be linear. METHODS: This cross-sectional study included 227 community-dwelling elders (age 65+ years). Multivariable regression analyses were performed to investigate the association between retinal nerve fiber layer/GC-IPL and global/domain-specific cognition. RESULTS: ). Similar associations were also found for logical memory. No significant association was observed between retinal nerve fiber layer and cognition. DISCUSSION: Either thinning or thickening of GC-IPL was associated with poor cognition in nondemented elderly (a U-shaped association). GC-IPL may serve as a noninvasive preclinical predictor of Alzheimer's disease.
Publisher
Elsevier Inc
Type
journal article