Rapid Synthesis of a Natural Product-Inspired Uridine Containing Library
Journal
ACS Combinatorial Science
Journal Volume
22
Journal Issue
11
Pages
600-607
Date Issued
2020
Author(s)
Abstract
The preparation of natural product-inspired nucleoside analogs using solution-phase parallel synthesis is described. The key intermediates containing alkyne and N-protected amino moieties were developed to allow for further skeleton and substituent diversity using click chemistry and urea or amide bond formation. Rapid purification was accomplished using solid-phase extraction. The obtained library comprised 80 molecules incorporating two diversity positions and one chiral center, each of which was efficiently prepared in good purity and acceptable overall yield. A bacterial morphology study was also performed. ? 2020 American Chemical Society. All rights reserved.
SDGs
Type
journal article