Age, sex and vitamin status affect plasma level of homocysteine, but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese
Journal
British Journal of Haematology
Journal Volume
117
Journal Issue
1
Pages
159-163
Date Issued
2002
Author(s)
Abstract
The biological effects of age, sex and vitamin status on plasma total homocysteine (tHcy), and association of hyperhomocysteinaemia with venous thromboembolism in Taiwanese Chinese individuals, were investigated. Eighty patients (16-85 years) with venous thrombophilia and 123 healthy subjects (15-85 years) without history of vascular thrombosis were studied for plasma levels of tHcy, folate and vitamin B12. A multivariate analysis in healthy subjects revealed that plasma tHcy levels tended to increase with age (P < 0.001) and with decreasing plasma levels of folate (P = 0.001) or vitamin B12 (P < 0.029); men tended to have higher plasma tHcy levels than women (P = 0.006). Thrombotic risk assessment in a case-control study demonstrated that neither plasma level of tHcy [odds ratio (OR), 1.07; 95% confidence interval (CI), 0.96-1.18; P = 0.210] nor hyperhomocysteinaemia (OR, 1.65; 95% CI, 0.50-5.49; P = 0.415) was significantly associated with venous thrombophilia. The relationship between hyperhomocysteinaemia and recurrence of episode remained insignificant (P = 0.560). We conclude that age, sex and vitamin status affect plasma tHcy but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese.
SDGs
Other Subjects
cyanocobalamin; folic acid; homocysteine; adolescent; aged; anamnesis; article; blood level; Chinese; confidence interval; controlled study; disease association; female; human; hyperhomocysteinemia; major clinical study; male; multivariate analysis; patient care; priority journal; recurrent disease; risk assessment; risk factor; Taiwan; thrombophilia; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Case-Control Studies; China; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nutritional Status; Odds Ratio; Risk Factors; Sex Factors; Taiwan; Thrombophilia; Vitamin B 12
Type
journal article