Clinical Outcomes of Taiwanese Patients with cT4 Oral Cavity Squamous Cell Carcinoma: Toward the Identification of the Optimal Initial Treatment Approach for cT4b Patients
Journal
Annals of Surgical Oncology
Journal Volume
24
Journal Issue
3
Pages
785-793
Date Issued
2017
Author(s)
Liao C.-T
Wen Y.-W
Lee S.R
Liu T.-W
Tsai S.-T
Tsai M.-H
Lin J.-C
Chu P.-Y
Leu Y.-S
Tsai K.-Y
Terng S.-D
Chen T.-M
Wang C.-H
Chien C.-Y
Chen W.-C
Lee L.-Y
Lin C.-Y
Wang H.-M
Ng S.-H
Lin C.-H
Fang T.-J
Huang S.-F
Kang C.-J
Chang K.-P
Yang L.Y
Yen T.-C
for the Taiwan Oral Cancer Advisory Group
Abstract
Background: The National Comprehensive Cancer Network guidelines recommend that patients with oral cavity squamous cell carcinoma (OSCC) and cT4b disease should be either included in clinical trials or treated with a nonsurgical approach. However, surgery may be feasible in selected patients with adequate safety margins. Using the nationwide Taiwanese Cancer Registry Database, we examined the prognosis of cT4b OSCC patients in relation to their treatment approach. Methods: Of the 18,910 patients with previously untreated first primary OSCC identified between 2004 and 2010, 492 (2.6?%) had cT4b tumors. Of them, 327 (66?%) received initial treatment with surgery, whereas 165 (34?%) were initially treated with a nonsurgical approach. Of the latter group, 78 patients subsequently underwent surgery. A 5-year disease-specific survival (DSS) ?45?% was considered as a favorable outcome. Results: Better 5-year DSS and overall survival (OS) rates were observed in cT4b patients initially treated with surgery (vs. nonsurgery; DSS, 51 vs. 38?%; OS, 43 vs. 27?%, respectively, p?
SDGs
Other Subjects
aged; Article; cancer classification; cancer incidence; cancer prognosis; cancer survival; Charlson Comorbidity Index; clinical outcome; conservative treatment; disease specific survival; female; human; major clinical study; male; mouth squamous cell carcinoma; outcome assessment; overall survival; prognostic assessment; survival rate; Taiwanese; adult; cancer staging; lymph node metastasis; middle aged; mouth tumor; multimodality cancer therapy; pathology; prognosis; radiotherapy; secondary; squamous cell carcinoma; Taiwan; antineoplastic agent; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Prognosis; Radiotherapy; Survival Rate; Taiwan
Publisher
Springer New York LLC
Type
journal article