The development of leukocyte removal filter by using PP-nonwoven and EVAL-coated Polyester fibers
Date Issued
2010
Date
2010
Author(s)
Huang, Wan-Chen
Abstract
Many papers have proven that transfusion reactions and infections after transfusions are caused by leukocytes in blood and blood components. In order to decrease above side effects , leucoreduction of blood products is the most important aspect. In this study, the researcher used different materials from commercial filters to develop a new, highly efficient leukocyte removal filter for red blood cell concentrates. Firstly, the principal used melt-blown nonwoven Polypropylene (PP-NW) and was coated with poly（ethylene-co-vinyl alcohol）(EVAL) on a Polyester fiber (PET) to take advantage of chemical adhesion properties and the physical porosity structure for studying the blood filtration research. Secondly, the functions of commercial filters were tested, then post-filtration blood counted by Automated haematology cell counting device and Nageotte counting chamber, to compare the efficiency with the study filter. Finally, the surface structure and blood cell morphology on the materials of PP-NW and PET coated EVAL were observed under Scanning Electron Microscope (SEM). At present, the results have shown that three kinds of commercial filters were not good enough, due to the blood samples having higher viscosity. The study filter could remove 98.94% of the leukocytes and recover over 94.87% of the erythrocytes, thus the efficiency was greater than that of current commercial filters, and had potential for such.
Subjects
leukocyte removal filter
EVAL
PP-NW
PET
filtration
efficiency
coated
Type
thesis
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