The Effects of Aging on Glucose Metabolism
Resource
台灣老年醫學暨老年學雜誌 v.4 n.1 pp.27-38
Journal
台灣老年醫學暨老年學雜誌,v.4
Journal Issue
n.1
Pages
27-38
Date Issued
2009
Date
2009
Author(s)
SHIH, SHYANG-RONG
Abstract
Type 2 diabetes mellitus is the most common chronic metabolic disease/ disorder in the elderly. The prevalence and incidence of impaired glucose tolerance and diabetes mellitus increase with aging. In Taiwan, the prevalence of diabetes mellitus increases with age and is approximately 20 % in those aged 65 years or older. The incidence of diabetes mellitus is also increasing in Taiwan. In an epidemiologic study which showed an average incidence of 9.3 per 100,000 population in those aged <35 and 725. 8 per 100,000 population in those aged ≥65 years. Responsible mechanisms of age-related glucose intolerance include decreased insulin sensitivity and decreased β-cell function . Decreased β-cell function may be related to glucotoxicity and mitochondrial dysfunction. Insulin resistance is related to mitochondrial dysfunction and increased intramyocytic triglyceride. Decreased number of insulin receptors, decreased AMP-activated protein kinase (AMPK) activity, decreased adiponectin and increased leptin are other postulated factors. Further studies are necessary to examine these hypotheses, to find out the key afflicting factors, and to work up as the target.
SDGs
Type
journal article