The Development of collagen-chitosan Dermal Filler or long-term stability
Date Issued
2009
Date
2009
Author(s)
Chen, Bo-Chung
Abstract
In recent decades, facial wrinkles is becoming the embarrassed question in developed countries. These minimally invasive procedures are becoming more popular with those who want to avoid having cosmetic surgery. Dermal filler is one of minimally invasive cosmetic procedures . Dermal filler is populated to cure the fine lines、rhytids and overlying folds.lthough some injectable agents was approved by the US Food and Drug Administration(FDA) but the ideal dermal filler has continued quest .n order to find the ideal dermal filler, we use the new material, which include porcine collagen and chitosan to achieve the goal which is long-lasting soft-tissue augmentation without side effects.n this study,the collagen-chitosan gel is investigated.The cross-linking agents is glutaradehyde. For the results,the gel viscosity is increased when collagen blended with chitosan and our material may be suitable for syringe injection.For in vitro,the cytotoxicity show that collagen-chitosan gel is biocompatible.In the test of degradation, results showed that collagen blended with chitosan may slow degradation when soaking in collagenase solution.The feature of collagen-chitosan gel is potential application to dermal filler.
Subjects
Dermal filler
Collagen
Chitosan
Cross-linking agent
Type
thesis
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