Independent association between triglycerides and coronary artery disease in Taiwanese type 2 diabetic patients
Journal
International Journal of Cardiology
Journal Volume
111
Journal Issue
1
Pages
80-85
Date Issued
2006
Author(s)
Abstract
Background: This study evaluated the association between triglycerides (TG) and coronary artery disease (CAD) in Taiwanese adults with type 2 diabetes mellitus (T2DM). Methods: A total of 1150 patients (542 men and 608 women) aged 62.5 ± 11.6 years were studied. CAD was diagnosed by history or an abnormal electrocardiogram (coronary probable or possible by Minnesota codes). Age, body mass index (BMI), smoking, use of insulin, anti-hypertensive agents and lipid-lowering agents, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were considered as potential confounders. Results: Patients with CAD were older, had higher prevalences of use of anti-hypertensive and lipid-lowering agents, and had higher BMI, SBP, DBP and TG. CAD increased significantly with increasing quartiles of TG (P-trend < 0.001). Ln(TG) was significantly correlated with BMI, FPG, HbA1c, DBP, TC, HDL-c (inversely) and LDL-c. Ln(TG) was associated with CAD with an unadjusted odds ratio of 1.411 (1.145-1.740). The odds ratio after adjustment for all confounders was slightly attenuated but still statistically significant: 1.380 (1.043-1.826). None of the other lipid parameters of TC, HDL-c and LDL-c were significantly associated with CAD in logistic models when they were entered for adjustment either separately or simultaneously. Sensitivity analyses by using history alone or history and coronary probable as diagnostic criteria for CAD did not change the association between TG and CAD. Conclusions: TG is an independent risk factor for CAD in Taiwanese T2DM, independent of TC, HDL-c, LDL-c or other confounders. ? 2005 Elsevier Ireland Ltd. All rights reserved.
SDGs
Other Subjects
antihypertensive agent; antilipemic agent; cholesterol; glucose; hemoglobin A1c; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; adult; age distribution; aged; article; body mass; cardiovascular risk; cholesterol blood level; controlled study; coronary artery disease; diagnostic approach route; diastolic blood pressure; disease association; ECG abnormality; female; glucose blood level; hemoglobin blood level; hemoglobin determination; human; hypertriglyceridemia; insulin treatment; logistic regression analysis; major clinical study; male; non insulin dependent diabetes mellitus; patient coding; patient information; priority journal; risk factor; sample size; sensitivity analysis; sex ratio; smoking; statistical significance; systolic blood pressure; Taiwan; triacylglycerol blood level; Aged; Coronary Arteriosclerosis; Coronary Artery Disease; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Taiwan; Triglycerides
Type
journal article