The significance of body weight change in non-Hodgkins lymphoma
Journal
Anticancer Research
Journal Volume
19
Journal Issue
6 C
Pages
5607-5610
Date Issued
1999
Author(s)
Abstract
Background: The purpose of this study was to evaluate the effect of weight changes after completion of chemotherapy on the prognosis and survival of patients with intermediate and high grade non-Hodgkin's lymphoma. Materials and Methods: A retrospective analysis of data on patients from the TCOG T1488 protocol, a phase II study using CHOP in the treatment of intermediate and high grade lymphoma. From September, 1988 to December 1994, 138 adult patients had complete weight data for analysis. Weight gain in lymphoma patients after therapy significantly correlated with improved survival (Logrank test p =. 0031). In patients with initial B symptoms, weight gain after therapy correlated with survival (Logrank test p=. 0039), female patients (odds ratio = 6.2) were less likely to gain weight on treatment. Conclusion: Weight gain after chemotherapy for lymphoma is a significant positive prognostic factor for survival.
Subjects
B symptoms; Lymphoma; Response; Survival; Weight changes
SDGs
Other Subjects
cyclophosphamide; doxorubicin; prednisolone; vincristine; adult; article; B cell lymphoma; body weight; cancer chemotherapy; cancer grading; cancer survival; clinical trial; female; human; major clinical study; male; nonhodgkin lymphoma; priority journal; prognosis; retrospective study; sex difference; weight gain; Adult; Aged; Body Weight; Female; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prognosis; Retrospective Studies
Type
journal article