Tellurium-nanowire-coated glassy carbon electrodes for selective and sensitive detection of dopamine
Journal
Biosensors & bioelectronics
Journal Volume
35
Journal Issue
1
Pages
479
Date Issued
2012-05-15
Author(s)
Abstract
Tellurium-nanowire-coated glassy carbon electrodes (TNGCEs) have been fabricated and employed for selective and sensitive detection of dopamine (DA). TNGCEs were prepared by direct deposition of tellurium nanowires, 600 ± 150 nm in length and 16 ± 3 nm in diameter, onto glassy carbon electrodes, which were further coated with Nafion to improve their selectivity and stability. Compared to the GCE, the TNGCE is more electroactive (by approximately 1.9-fold) for DA, and its selectivity toward DA over ascorbic acid (AA) and uric acid (UA) is also greater. By applying differential pulse voltammetry, at a signal-to-noise ratio of 3, the TNGCE provides a limit of detection of 1 nM for DA in the presence of 0.5mM AA and UA. Linearity (R(2)=0.9955) of the oxidation current at 0.19 V against the concentration of DA is found over the range 5 nM-1 μM. TNGCEs have been applied to determine the concentration of dopamine to be 0.59 ± 0.07 μM in PC12 cells.
Subjects
Te nanowires; Dopamine; Differential pulse voltammetry; PC12 cells; Electrochemical detection; ASCORBIC-ACID; URIC-ACID; CAPILLARY-ELECTROPHORESIS; LIQUID-CHROMATOGRAPHY; RELEASE; QUANTIFICATION; CELL
Publisher
ELSEVIER ADVANCED TECHNOLOGY
Type
journal article