Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the K(ATP) channel and insulin secretion in rats
Journal
Diabetologia
Journal Volume
52
Journal Volume
52
Journal Issue
6
Journal Issue
6
Pages
1112
Start Page
1112
End Page
1121
ISSN
1432-0428
Date Issued
2009-06
Author(s)
Abstract
Rosiglitazone, an insulin sensitiser, not only improves insulin sensitivity but also enhances insulin secretory capacity by ameliorating gluco- and lipotoxicity in beta cells. Rosiglitazone can stimulate insulin secretion at basal and high glucose levels via a phosphatidylinositol 3-kinase (PI3K)-dependent pathway. We hypothesised that regulation of phosphorylation of the ATP-sensitive potassium (K(ATP)) channel might serve as a key step in the regulation of insulin secretion.
Subjects
AMP-activated protein kinase; Insulin secretion; K-ATP channel; Serine phosphorylation; Rosiglitazone; BETA-CELL FUNCTION; SENSITIVE POTASSIUM CHANNELS; ACTIVATED RECEPTOR-GAMMA; PANCREATIC-ISLETS; PHOSPHATIDYLINOSITOL 3-KINASE; PEROXISOME PROLIFERATOR; TROGLITAZONE CS-045; SIGNALING PATHWAYS; DIABETES-MELLITUS; GENE-EXPRESSION
SDGs
Publisher
SPRINGER
Type
journal article