Living-related liver transplantation for methylmalonic acidemia: Report of one case
Journal
Acta Paediatrica Taiwanica
Journal Volume
44
Journal Issue
3
Pages
171-173
Date Issued
2003
Author(s)
Hsui J.-Y.
Chu S.-Y.
Ho M.-J.
Abstract
Methylmalonic acidemia (MMA) is an autosomal recessive disease of branched chain amino acid metabolism. The disease can be classified as vitamin B12-responsive or nonresponsive type. For the nonresponsive type, there is no curative treatment, and its prognosis is usually poor. We report one case that had vitamin B12-nonresponsive type MMA diagnosed at 3 days of age. The patient received liver transplantation at the age of 11 months. Continuous venovenous hemodialysis was performed immediately pre-and post-transplantation. The attack frequency of metabolic acidosis episodes decreased and the general condition of this patient improved after liver transplantation. So, although not curative, liver transplantation is an effective management for MMA.
SDGs
Other Subjects
bicarbonate; cyanocobalamin; cyclosporin; Cytomegalovirus antibody; ganciclovir; glucose; methylprednisolone; misoprostol; tacrolimus; amino acid metabolism; article; case report; cytomegalovirus infection; disease classification; disease course; drug induced disease; female; hemodialysis; human; infant; liver transplantation; living donor; methylmalonic acidemia; pneumonia; postoperative period; preoperative care; prognosis; protein restriction; treatment outcome; Amino Acid Metabolism, Inborn Errors; Female; Humans; Infant; Liver Transplantation; Living Donors; Methylmalonic Acid
Type
journal article