Stimulated resistin expression in white adipose of rats with bile duct ligation-induced liver cirrhosis: relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha
Resource
Molecular & Cellular Endocrinology 232, 1–8
Journal
Molecular & Cellular Endocrinology 232, 1–8
Pages
-
Date Issued
2005-01-18
Date
2005-01-18
Author(s)
DOI
246246/2006111501222468
Abstract
Resistin, an adipose-derived polypeptide hormone, is proposed as a candidate of insulin resistance, although its roles in inhibiting adipogenesis & in inflammation have also been suggested. Liver cirrhosis is characterized by elevated circulating proinflammatory cytokines, including tumor necrosis factor- (TNF-), hyperinsulinemia & insulin resistance. The study aimed to examine resistin expression & its association with insulin & TNF- in a cirrhotic rat model using bile duct ligation (BDL). The BDL-induced cirrhotic rats showed significantly lower fat mass, insulin sensitivity & elevated plasma insulin & TNF- compared to sham animals. In addition, epididymal TNF- & resistin mRNA & protein levels were higher in cirrhotic rats. In normal control rats, in vivo insulin infusion & ex vivo administration of TNF- to cultured fat pads increased resistin gene expression significantly. These results implied that hyperinsulinemia & increased TNF- levels might upregulate adipose resistin gene in BDL-induced liver cirrhosis. Further study is necessary to document the role of resistin in metabolic abnormalities of liver cirrhosis.
Subjects
Hyperinsulinemia
Liver cirrhosis
Resistin
Tumor necrosis factor-
Publisher
Taipei:National Taiwan University Dept Chem Engn
Type
journal article
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