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  4. The impact of nonmotor symptoms on quality of life in patients with parkinson's disease in Taiwan
 
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The impact of nonmotor symptoms on quality of life in patients with parkinson's disease in Taiwan

Journal
Neuropsychiatric Disease and Treatment
Journal Volume
11
Pages
2865-2873
Date Issued
2015
Author(s)
Liu W.-M.
Lin R.-J.
Yu R.-L.
CHUN-HWEI TAI  
CHIN-HSIEN LIN  
RUEY-MEEI WU  
DOI
10.2147/NDT.S88968
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947076382&doi=10.2147%2fNDT.S88968&partnerID=40&md5=46b1756ba91e1f92719ff7a7cebe0a6b
https://scholars.lib.ntu.edu.tw/handle/123456789/520124
Abstract
Purpose: The nonmotor symptoms (NMS) of Parkinson’s disease (PD) are important factors for quality of life (QoL). Few studies on NMS have been conducted in Asian PD patients. Additionally, effects of anti-PD drugs on risk of NMS are still controversial. We therefore conducted this hospital-based cross-sectional study to examine the clinical factors, including concomitant anti-PD medication use, on the occurrence of NMS and QoL in Taiwanese PD patients. Patients and methods: PD patients who received long-term follow-up in the movement disorders clinics were enrolled and received NMS questionnaire (NMSQuest) and the 39-item Parkinson’s Disease Questionnaire (PDQ-39). Spearman’s rank correlation coefficient was checked for the correlation between clinical factors and NMSQT/PDQSI. Multiple linear regressions were applied to assess the influence of clinical factors on NMSQT/PDQSI. Results: A total of 210 PD patients (mean age 66.1±9.86 years, Hoehn and Yahr stage 2.2±0.9) were included in this study. Up to 98% of patients reported at least one symptom of NMS. The most prevalent symptom was urinary complaints (56%), followed by memory/apathy (30%) and depression/anxiety (28%). The correlation between NMSQT and PDQSI was strong (rs=0.667), especially the item of depression/anxiety (rs=0.607). The regression model for NMSQT indicated that disease duration and severity, but not pharmacological therapy, were major predictors of NMS. Conclusion: Our data indicated a high prevalence rate of NMS in PD patients. Among symptoms of NMS, depression and anxiety had the greatest impact on QoL. Concomitant anti-PD medication use did not affect the occurrence of NMS and QoL. ? 2015 Liu et al.
SDGs

[SDGs]SDG3

Other Subjects
levodopa; adult; aged; anxiety; apathy; Article; constipation; cross-sectional study; depression; disease association; disease duration; disease severity; drug use; feces incontinence; female; Hoehn and Yahr scale; human; major clinical study; male; memory disorder; nocturia; nonmotor symptom; nonmotor symptom questionnaire; Parkinson disease; Parkinson Disease Questionnaire 39; predictive value; prevalence; quality of life; questionnaire; risk factor; sex difference; sexual dysfunction; symptom; Taiwan; urinary complaint; urinary dysfunction
Publisher
Dove Medical Press Ltd.
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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