Connective tissue growth factor (CTGF) and cancer progression
Journal
Journal of Biomedical Science
Journal Volume
15
Journal Issue
6
Pages
675-685
Date Issued
2008
Author(s)
Abstract
Connective tissue growth factor (CTGF) is a member of the CCN family of secreted, matrix-associated proteins encoded by immediate early genes that play various roles in angiogenesis and tumor growth. CCN family proteins share uniform modular structure which mediates various cellular functions such as regulation of cell division, chemotaxis, apoptosis, adhesion, motility, angiogenesis, neoplastic transformation, and ion transport. Recently, CTGF expression has been shown to be associated with tumor development and progression. There is growing body of evidence that CTGF may regulate cancer cell migration, invasion, angiogenesis, and anoikis. In this review, we will highlight the influence of CTGF expression on the biological behavior and progression of various cancer cells, as well as its regulation on various types of protein signals and their mechanisms. ? 2008 National Science Council Taipei.
SDGs
Other Subjects
connective tissue growth factor; angiogenesis; anoikis; cancer cell; cancer growth; cancer invasion; carcinogenesis; cell invasion; cell migration; human; metastasis; nonhuman; priority journal; protein expression; review; Anoikis; Cell Movement; Connective Tissue Growth Factor; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic
Type
review