Specific Stabilization of DNA Triple Helices by Indolo 2,1-B Quinazolin-6 ,12-Dione Derivatives
Resource
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS v.17 n.6 pp.1769-1772
Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Journal Volume
v.17
Journal Issue
n.6
Pages
1769-1772
Date Issued
2007
Date
2007
Author(s)
Abstract
Derivatives of indolo[2, 1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl group to the nitrogen adjacent to the planar core can enhance triplex stability by 6 degrees C and the effect is additive. Conformational analysis reveals that the orientation of the side chain underlies the ability of this compound to stabilize a DNA triplex. (c) 2006 Elsevier Ltd. All rights reserved.
Subjects
DNA triplex
triplex stabilizing agents
tryptanthrin
indolo[2
1-b]quinazolin-6
12-dione
thermal denaturation