Inhibition of cancer cell migration and invasion through suppressing the wnt1-mediating signal pathway by G-quadruplex structure stabilizers
Journal
Journal of Biological Chemistry
Journal Volume
289
Journal Issue
21
Pages
14612-14623
Date Issued
2014
Author(s)
Abstract
Background: The Wnt1 pathway is recognized to play a major role in cancer progression. Results: The promoter region of the WNT1 gene can form G-quadruplex structures, which regulate WNT1 expression and its downstream signaling pathways. Conclusion: The Wnt1-mediated migration and invasion activities of cancer cells are inhibited by G-quadruplex stabilizers. Significance: A pathway-specific strategy is identified to repress cancer metastasis using G-quadruplex stabilizers. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
SDGs
Other Subjects
Diseases; Gene expression; Cancer cells; Cancer metastasis; Cancer progression; G-quadruplex structure; G-quadruplexes; Promoter region; Signal pathways; Signaling pathways; Cells; beta catenin; guanine quadruplex; matrilysin; membrane protein; oligonucleotide; protein BMVC; protein BMVC4; survivin; unclassified drug; Wnt1 protein; article; cancer cell; cell invasion; controlled study; down regulation; drug research; gene expression regulation; gene overexpression; human; human cell; melting point; migration inhibition; priority journal; promoter region; protein analysis; protein stability; protein structure; protein targeting; signal transduction; Anticancer Drug; Cell Migration; DNA Structure; G-quadruplex; Promoters; Wnt Pathway; beta Catenin; Carbazoles; Cell Line, Tumor; Cell Movement; G-Quadruplexes; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins; Matrix Metalloproteinase 7; Neoplasm Invasiveness; Oligonucleotides; Promoter Regions, Genetic; Pyrazines; Pyridinium Compounds; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Wnt1 Protein
Publisher
American Society for Biochemistry and Molecular Biology Inc.
Type
journal article