Risk factor analysis for the immunogenicity of adalimumab associated with decreased clinical response in Chinese patients with psoriasis
Journal
Acta Dermato-Venereologica
Journal Volume
95
Journal Issue
6
Pages
711-716
Date Issued
2015
Author(s)
Abstract
Although anti-drug antibodies against biologics have been associated with decreased clinical efficacy, the immunogenicity of biologics seems to vary between drugs, diseases and ethnicities. This study aims to investigate the predictors for the formation of anti-adalimumab antibodies (AAA) and the clinical consequences of AAA formation. In 53 Chinese psoriatic patients treated with adalimumab, AAA was detected in 50.9%. Differences in Psoriasis Area and Severity Index 75 (PASI75) response rates among patients with and without AAA were significant (44.4% vs. 88.5%; p = 0.001). Patients with AAA had significantly lower trough concentrations of adalimumab than those without AAA. Risk factor analysis showed that treatment interruption, low trough adalimumab concentration, absence of concomitant methotrexate use and biologics switching were associated with a higher AAA titre. The treatment pattern of biologics influences the risk of AAA formation, thereby leading to reduced efficacy of adalimumab. ? 2015 The Authors.
SDGs
Other Subjects
adalimumab; biological product; drug antibody; methotrexate; tumor necrosis factor alpha inhibitor; adalimumab; antibody; immunosuppressive agent; methotrexate; nonsteroid antiinflammatory agent; adult; antibody production; antibody titer; Article; Chinese; drug blood level; drug efficacy; female; human; immunogenicity; loading drug dose; low drug dose; major clinical study; male; middle aged; minimum plasma concentration; monotherapy; priority journal; Psoriasis Area and Severity Index; psoriasis vulgaris; psoriatic arthritis; risk factor; statistical significance; treatment response; blood; China; drug combination; drug resistance; drug substitution; immunology; psoriasis; retrospective study; severity of illness index; Adalimumab; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; China; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Risk Factors; Severity of Illness Index
Publisher
Medical Journals/Acta D-V
Type
journal article