Decreased serum level of lipoprotein cholesterol is a poor prognostic factor for patients with severe community-acquired pneumonia that required intensive care unit admission
Journal
Journal of Critical Care
Journal Volume
30
Journal Issue
3
Pages
506-510
Date Issued
2015
Author(s)
Abstract
Purpose: The purpose of this study is to investigate the prognostic values of the serum levels of lipids in patients with severe community-acquired pneumonia (CAP) that required intensive care unit (ICU) admission. Materials and methods: Patients who had severe CAP that required ICU admission were included. Serum lipid level was collected on the days 1 and 7 of ICU stay. Clinical outcome, including length of ICU stay, hospital stay, and death, were monitored prospectively. Results: A total of 40 patients were enrolled in this study. Lower high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were found in nonsurvival group on ICU admission day 7 (survivors vs nonsurvivors; mean HDL, 41.8 vs 13.0 mg/dL, P = .002; LDL, 62.3 vs 30.3 mg/dL, P = 0.006, respectively). High-density lipoprotein cholesterol level of less than or equal to 17 mg/dL on day 7 (odds ratio, 1.23) and LDL cholesterol level of less than or equal to 21 mg/dL on day 7 (odds ratio, 1.10) could be a predictor of hospital mortality. The mean change in levels of HDL cholesterol in nonsurvivors decreased significantly than those in survivors from days 1 to 7 (8.5 vs -. 17.4 mg/dL, P = .04) but not LDL cholesterol. Conclusions: Decreased serum HDL cholesterol level from days 1 to 7 may be of prognostic value. ? 2015 Elsevier Inc.
SDGs
Other Subjects
high density lipoprotein cholesterol; lipid; lipoprotein; low density lipoprotein cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; adult; Article; cholesterol blood level; clinical article; community acquired pneumonia; controlled study; disease severity; female; hospital admission; hospitalization; human; intensive care unit; length of stay; lipid blood level; lipoprotein blood level; male; mortality; prognosis; prospective study; aged; blood; cohort analysis; community acquired infection; disease course; middle aged; pneumonia; very elderly; Aged; Aged, 80 and over; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Community-Acquired Infections; Disease Progression; Female; Hospital Mortality; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Pneumonia; Prognosis; Prospective Studies
Type
journal article