Preliminary evidence of polymorphisms of cell cycle regulatory genes and their roles in urinary tract urothelial cancer susceptibility and prognosis in a Taiwan population
Journal
Urologic Oncology: Seminars and Original Investigations
Journal Volume
35
Journal Issue
9
Pages
543.e7-543.e16
Date Issued
2017
Author(s)
Lin Y.-C.
Hour T.-C.
Huang S.-P.
Wu W.-J.
Chung S.-D.
Abstract
Objective Our aims were to investigate the correlations between polymorphisms in the cell cycle regulatory genes (aurora kinase A [AURKA], survivin, p21, and p53) and UC risk and prognosis. Patients and methods This study recruited 185 patients with UTUC, 46 patients with bladder cancer, and 188 hospital controls. Demographic data and possible confounding factors were collected using a standardized questionnaire. Genotyping was determined by real-time polymerase chain reaction and TaqMan probe methods. Results Compared to the UTUC group, the control group had significantly more alcohol drinkers and coffee drinkers but not cigarette smokers. Statistical analyses showed that UTUC risk correlated with AURKA rs2273535 (adjusted odds ratio = 2.51, 95% CI = 1.07–6.15) and with survivin rs9904341 (adjusted odds ratio = 1.82, 95% CI = 1.03–3.26) polymorphisms but not with p21 and p53 polymorphisms. The bladder cancer risk showed no significant correlations with the 4 polymorphisms. In both the UTUC and UC groups, disease-free survival and overall survival were significantly longer in patients with the rs1801270CC genotype compared to those with CA+AA genotypes. Poor prognosis did not correlate with polymorphisms in AURKA, survivin, and p53 genes. Conclusion These results suggest that cell cycle regulatory gene polymorphisms rs2273535 and rs9904341 may contribute to UTUC susceptibility; gene polymorphism rs1801270 may contribute to prognosis of UTUC and prognosis of UC. The p53 polymorphisms may not correlate with UTUC susceptibility and prognosis of UTUC or UC. Further well-designed, large-scale studies are needed to clarify these findings. ? 2017
SDGs
Other Subjects
alcohol; aurora A kinase; protein p21; protein p53; survivin; adult; Article; bladder cancer; cancer diagnosis; cancer patient; cancer prognosis; cancer risk; cancer survival; cancer susceptibility; case control study; cell cycle regulation; coffee; controlled study; correlational study; demography; disease free survival; DNA polymorphism; drinking behavior; female; hospital based case control study; human; major clinical study; male; middle aged; overall survival; priority journal; questionnaire; real time polymerase chain reaction; regulator gene; smoking; Taiwan; tumor gene; urinary tract cancer; urogenital tract cancer; cell cycle; epidemiology; genetic polymorphism; genetic predisposition; genetics; pathology; urinary tract tumor; Cell Cycle; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Genetic; Taiwan; Urologic Neoplasms
Publisher
Elsevier Inc.
Type
journal article