Pulmonary IL-33 orchestrates innate immune cells to mediate RSV-evoked airway hyperreactivity and eosinophilia
Journal
Allergy
Date Issued
2019-10-17
Author(s)
Wu, Yi-Hsiu
Lai, Alan Chuan-Ying
Chi, Po-Yu
Thio, Christina Li-Ping
Chen, Wei-Yu
Tsai, Ching-Hui
Lukacs, Nicholas W
Chang, Ya-Jen
Abstract
Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL-33 is elevated and promotes immune cell activation, leading to the development of asthma. However, which immune cells are responsible for triggering airway hyperreactivity (AHR), inflammation and eosinophilia remained to be clarified. We aimed to elucidate the individual roles of IL-33-activated innate immune cells, including ILC2s and ST2+ myeloid cells, in RSV infection-triggered pathophysiology.
Subjects
IL-33; ILC2; asthma; eosinophilia; respiratory syncytial virus
SDGs
Publisher
WILEY
Type
journal article