Further study on anti-inflammatory oxygenated steroids from the octocoral Dendronephthya griffini
Resource
Steroids 73 (14): 1353-1358
Journal
Steroids
Journal Volume
73
Journal Issue
14
Pages
1353-1358
Date Issued
2008
Author(s)
Chao, Chih-Hua
Wen, Zhi-Hong
Su, Jui-Hsin
Chen, I-Ming
Huang, Ho-Cheng
Sheu, Jyh-Horng
Abstract
Five new steroids, namely griffinisterones F-I (1-4) and griffinipregnone (5) have been isolated from the octocoral Dendronephthya griffini. The structures of these compounds were elucidated by extensive spectroscopic analysis. Compounds 1-3 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells at 10 μM. At the same concentrations 2 also could significantly inhibit the accumulation of the pro-inflammatory COX-2 protein. © 2008 Elsevier Inc. All rights reserved.
Type
journal article
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