Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model
Journal
Journal of Neurosurgery
Journal Volume
129
Journal Issue
4
Pages
997
Date Issued
2018
Author(s)
Lee, Jing-Er
Huang, Sheng-Jean
Abstract
OBJECTIVE: Direct brain compression and secondary injury due to increased intracranial pressure are believed to be the pathognomic causes of a grave outcome in acute subdural hemorrhage (aSDH). However, ischemic damage from aSDH has received limited attention. The authors hypothesized that cerebral microcirculation is altered after aSDH. Direct visualization of microcirculation was conducted in a novel rat model. METHODS: ) were measured at various depths from the cortex. The brain was then sectioned for pathological examination. The effects of aspirin pretreatment were also examined. RESULTS: were found at depths of 2-4 mm. Blood-brain barrier disruption and thrombi formation were confirmed using immunohistochemical staining, while aspirin pretreatment reduced thrombosis and the impairment of microcirculation. CONCLUSIONS: Microcirculation impairment was demonstrated in this aSDH model. Aspirin pretreatment prevented the diffuse thrombosis of cortical and subcortical vessels after aSDH.
SDGs
Publisher
American Association of Neurological Surgeons
Type
journal article