Comment on 'Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler'
Journal
Physiological Measurement
Journal Volume
30
Journal Issue
10
Pages
L9-L11
Date Issued
2009
Author(s)
Abstract
The relationship between cerebral blood volume (CBV) and blood flow (CBF) has gained widespread interest because of its utility in using functional magnetic resonance imaging and optical imaging methods to estimate the cerebral metabolic rate of oxygen (CMRO2). A recent paper by Leung et al (2009 Physiol. Meas. 30 1-12) nicely presents measurements relating CBV to cerebral blood flow velocity (CBFV) as measured by near infrared spectroscopy and transcranial Doppler, respectively. They suggest that this relationship cannot be inverted to estimate CBF (or CBFV) from CBV, and that doing so to estimate CMRO2 is inappropriate. We argue that these data, and other related published data, do permit the estimation of CBF from CBV and thus enable CMRO2 to be estimated when only measures of CBV and deoxygenated hemoglobin are available. ? 2009 Institute of Physics and Engineering in Medicine.
Subjects
Blood
Blood vessels
Flow velocity
Hemodynamics
Infrared devices
Metabolism
Near infrared spectroscopy
Oxygen
Blood flow
Blood volumes
Cerebral blood flow
Cerebral blood flow velocities
Cerebral blood volume
Cerebral metabolic rate of oxygen
Functional magnetic resonance imaging
Grubb exponent
Metabolic rates
Transcranial Doppler
Magnetic resonance imaging
oxygen
article
brain blood flow
brain metabolism
Doppler echography
functional magnetic resonance imaging
human
near infrared spectroscopy
nuclear magnetic resonance imaging
priority journal
SDGs
Type
journal article